MPP NLT 98%

MPP is a highly selective estrogen receptor alpha (ERα) antagonist. MPP reduces the ratio of p-ERα/ERα^[1]. https://www.ncbi.nlm.nih.gov/pubmed/29799481 Labouesse MA, et al. Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice. Psychopharmacology (Berl). 2015 Aug;232(16):2981-94. https://www.ncbi.nlm.nih.gov/pubmed/25893642 In Vitro: MPP (1, 5, 10, 25, 50 and 100 µM; 24 h) decreases cell viability with an IC₅₀ value of 20.01 µM in RL95-2 cells^[1].
MPP dihydrochloride shows antiproliferative activity at a concentration of 10 μM in RL95-2 cells^[1].
MPP dihydrochloride (20 µM; 24 h) reduces the phosphorylation of ERα, while it does not alter the phosphorylation of Akt. MPP dihydrochloride reduces the ratio of p-ERα/ERα^[1]. In Vivo: MPP (Low dose 20 μg/kg body weight or high dose 200 μg/kg body weight) leads to a dose-dependent attenuation of percent prepulse inhibition (PPI)^[2].