Benzamil NLT 98%
SKU : MC546638
CAS Number : 2898-76-2
Molecular Formula : C13H14ClN7O | Molecular Weight : 319.75
Synonyms : Benzylamiloride
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | Benzamil |
|---|---|
| CAS Number | 2898-76-2 |
| MDL Number | MFCD05237236 |
| Molecular Formula | C13H14ClN7O |
| Molecular Weight | 319.75 |
| Synonyms | Benzylamiloride |
Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM[1][2][3]. In Vitro: Benzamil (Benzylamiloride) inhibits neuronal and heterologously expressed small conductance Ca2+-activated K2+ channels[4]. In Vivo: Benzamil (Benzylamiloride) (0.7 mg/kg/day; s.c.) treated stroke-prone spontaneously hypertensive rats (SHRSP) survived, on average, until 16.1 weeks of age in SHRSP rats[5].
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