SKU : MC546671
CAS Number : 290304-24-4
Molecular Formula : C41H44N2O20 | Molecular Weight : 884.79
Quote RequestPurity | NLT 98% |
---|---|
Storage | at 20ºC 2 years |
* The above information is for reference only.
* If the product has intellectual property rights, a license granted is must or contact us.
Chemical Name | Daun02 |
---|---|
CAS Number | 290304-24-4 |
MDL Number | MFCD22124459 |
Molecular Formula | C41H44N2O20 |
Molecular Weight | 884.79 |
Daun02 is converted by β-galactosidase to Daunorubicin, which is a topoisomerase inhibitor. IC50 & Target: Topoisomerase[1][2] In Vitro: Daun02 is a prodrug, which is converted by β-galactosidase to Daunorubicin, which has been shown to reduce calcium ion (Ca2+)-dependent action potentials in neuroblastoma cells[1]. Daunorubicin is a topoisomerase inhibitor[2]. Daun02 is a good substrate for β-galactosidase (β-gal). The concentration of Daun02 producing 50% (EC50) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively[3]. In Vivo: Daun02 is a good substrate for β-gal with Km and Vmax values of 0.37 mM and 8.6 μmol/min/mg protein. At a concentration of 10-5 M, Daun02 is 79% bound to plasma protein compares to 94% for Daunomycin[3].
© Copyright 2015-2024 Hangzhou MolCore BioPharmatech Co.,Ltd. All rights reserved.