SKU : MC546720
CAS Number : 29106-49-8
Molecular Formula : C30H26O12 | Molecular Weight : 578.52
Synonyms : Proanthocyanidin B2
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Procyanidin B2 |
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CAS Number | 29106-49-8 |
MDL Number | MFCD01861513 |
Molecular Formula | C30H26O12 |
Molecular Weight | 578.52 |
Synonyms | Proanthocyanidin B2 |
Procyanidin B2 is a natural flavonoid, with anti-cancer, antioxidant activities. In Vitro: Procyanidin B2 shows antiproliferative activity to MCF-7 cells, with an IC50 of 19.21 μM. However, Procyanidin B2 exhibits no effect on DNA-ladder formation[1]. Procyanidin B2 (0.1, 1, 2 μM) inhibits the activation of pyrin domain containing 3 (NLRP3) inflammasome in human umbilical vein ECs (HUVECs), and the inhibition is via suppression of AP-1 activity, and such effect can be abolished by overexpression of c-Jun. Procyanidin B2 (2 μM for 12 h) also reduces ROS in HUVECs[2]. In Vivo: Procyanidin B2 (40, 20, and 10 mg/kg, p.o.) protects against cerebral ischemia-induced infarct volume and brain edema in rats. Procyanidin B2 (40 mg/kg, p.o) also improves functional outcomes, regulates blood-brain barrier (BBB) permeability after cerebral ischemia. Moreover, Procyanidin B2 attenuates cerebral ischemia-induced tight junction degradation, mitochondrial depolarization and intracellular oxidative stress. Procyanidin B2 (40 mg/kg, p.o) increases Nrf2 activation and HO-1, GSTα, and NQO1 protein expression in normal brains in vivo[3].
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