SKU : MC546783
CAS Number : 29261-12-9
Molecular Formula : C27H44O3 | Molecular Weight : 416.64
Synonyms : 25,26-Dihydroxycholecalciferol
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | 25,26-Dihydroxyvitamin D3 |
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CAS Number | 29261-12-9 |
MDL Number | MFCD03787937 |
Molecular Formula | C27H44O3 |
Molecular Weight | 416.64 |
Synonyms | 25,26-Dihydroxycholecalciferol |
25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity. IC50 value: Target: VD metabolite The biological activity of synthetic 24,25 and 25,26 diOHD3 was studied in vitamin D-deficient rats. The purpose of this study was to investigate the influence of small doses of both metabolites (0.125-0.250 mug) upon intestinal calcium transport and bone calcium mobilization. Both metabolites were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The "bone calcium mobilization" of both derivatives was measured in vitamin D and calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 and 25,26 diOHD3 increased serum calcium moderately, but the increment was only significant with 24,25 diOHD3.
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