L-685458 NLT 98%
SKU : MC546788
CAS Number : 292632-98-5
Molecular Formula : C39H52N4O6 | Molecular Weight : 672.85
Synonyms : L-685,458
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | L-685458 |
|---|---|
| CAS Number | 292632-98-5 |
| MDL Number | MFCD03093402 |
| Molecular Formula | C39H52N4O6 |
| Molecular Weight | 672.85 |
| Synonyms | L-685,458 |
L-685458 is a potent inhibitor of Amyloid β-Protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. IC50 value: 17 nM Target: γ-secretase in vitro: L-685458 is a Notch inhibitor. L-685458 blocks Notch activation in the two cell lines in terms of reduced cytoplasmic distribution and almost diminished nuclear labelling of Hes1 proteins. [2] L-685458 is a γ-secretase inhibitor. [3]
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