SKU : MC547060
CAS Number : 298690-60-5
Molecular Formula : C17H18FNO2S | Molecular Weight : 319.39
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Ro 67-7476 |
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CAS Number | 298690-60-5 |
MDL Number | MFCD20270617 |
Molecular Formula | C17H18FNO2S |
Molecular Weight | 319.39 |
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. Displays no activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM. target: mGlu1 EC 50: 60.1 nM (1) Ro 67-7476 (10 μM) can directly block the GIRK channel (to 67 ± 2% of control). (2) Ro 67-7476 enhance the glutamate-induced current in all chimeric receptors containing the transmembrane (TM) region of rmGlu1a (R1, R1-R5N, R1-R5C, and R5-R1TM) but not in those containing the TM region of rmGlu5a (R5, R5-R1N, R5-R1C, and R1-R5TM. (3) The application of Ro 67-7476 (3 μM) produced no effect alone but resulted in a marked potentiation of the mGlu1 EPSC amplitude.
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