SKU : MC547804
CAS Number : 3105-97-3
Molecular Formula : C20H24N2O2S | Molecular Weight : 356.48
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Hycanthone |
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CAS Number | 3105-97-3 |
MDL Number | MFCD00083383 |
Molecular Formula | C20H24N2O2S |
Molecular Weight | 356.48 |
Hycanthone is an effective antischistosomai drug. IC50 & Target: Parasite[1] In Vitro: Hycanthone at 20 mg/mL or more is progressively more detrimental to cell viability. Results reveal that increased concentrations of Hycanthone, ranging from 0.1 to 10 μg/mL, progressively reduces viral interferon yields as much as 73% compare to that of controls[2]. In Vivo: Results show that the incorporation of tritiated thymidine into TCA-precipitable material of adult sensitive worms undergo a progressive decrease after treatment with Hycanthone. Immature worms are totally unaffected by Hycanthone at all times tested. Male worms treated with Hycanthone show signs of a possible partial recovery from the initial low levels of incorporation. The incorporation of tritiated leucine by drug-sensitive worms treated with Hycanthone is inhibited by 40 to 50% in the first four days after treatment. Results show that, 7 days after Hycanthone treatment, both ribosomal RNA species are reduced by at least 80% with respect to untreated worms, with some indication of a possible accumulation of heavier precursor molecules[1].
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