KH7 NLT 98%
Product Number : MC549011
CAS Number : 330676-02-3
Molecular Formula : C17H15BrN4O2S | Molecular Weight : 419.30
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
| MolCore specializes in manufacturing high-purity CAS No.330676-02-3, KH7 with the molecular formula C17H15BrN4O2S and molecular weight 419.30 delivering critical API intermediates for global pharmaceutical and research industries, certified under ISO quality systems. | |
* The above information is for reference only.
| Chemical Name | KH7 |
|---|---|
| CAS Number | 330676-02-3 |
| MDL Number | MFCD01230899 |
| Molecular Formula | C17H15BrN4O2S |
| Molecular Weight | 419.30 |
KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays[1]. KH7 is also a cAMP inhibitor[2]. IC50 & Target: IC50: 3-10 μM (recombinant sACt)[1]. In Vitro: KH7 (10 μM) blocks this capacitation-induced cAMP increase. At higher concentrations (50 μM), 5- to 10-fold above its IC50 but still selective for sAC relative to tmACs, KH7 resulted in a significant decrease in the basal cAMP accumulation in sperm regardless of the incubation medium[1].
KH7 prevents the generation of CaSF[2].
In the presence of KH7, the myocytes exerts a negative inotropic effect (NIE) of approximately 20%, suggesting that sAC is involved in the normal generation of basal cardiac contractility[2].
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