Hypophyllanthin NLT 98%
SKU : MC549467
CAS Number : 33676-00-5
Molecular Formula : C24H30O7 | Molecular Weight : 430.49
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
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| Chemical Name | Hypophyllanthin |
|---|---|
| CAS Number | 33676-00-5 |
| MDL Number | MFCD03424459 |
| Molecular Formula | C24H30O7 |
| Molecular Weight | 430.49 |
Introduction of 33676-00-5 :
Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2]. IC50 & Target: P-gp[2] In Vitro: Hypophyllanthin down-regulates COX-2, TNF-α, and IL-1β gene expressions in U937 macrophages by interfering with the activation of NF-κB, MAPKs, and Akt[1].
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