SKU : MC549956
CAS Number : 34433-31-3
Molecular Formula : C14H16Cl2N4O3 | Molecular Weight : 359.21
Synonyms : HI-6
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Asoxime (dichloride) |
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CAS Number | 34433-31-3 |
MDL Number | MFCD00869535 |
Molecular Formula | C14H16Cl2N4O3 |
Molecular Weight | 359.21 |
Synonyms | HI-6 |
Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system[1]. IC50 & Target: IC50: acetylcholine receptors (AChRs)[1] In Vivo: Asoxime dichloride (intramuscular injection into the rear limb; 2% and 0.2% of median lethal dose 15.6 and 1.56 mg/kg; 21 or 65 days) significantly improved vaccination efficacy as a dose-dependent manner when KLH is 1 mg/kg. A combination of HI-6 and keyhole limpet hemocyanin (KLH) produces a vaccination of almost the same efficacy as that for Freund's complete adjuvant[1].
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