SKU : MC550170
CAS Number : 347174-05-4
Molecular Formula : C15H22N2O2 | Molecular Weight : 262.35
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Ferrostatin-1 |
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CAS Number | 347174-05-4 |
MDL Number | MFCD08072959 |
Molecular Formula | C15H22N2O2 |
Molecular Weight | 262.35 |
Ferrostatin-1 is a potent inhibitor of ferroptosis with an EC50 of 60 nM. IC50 & Target: EC50: 60 nM (Ferroptosis)[1] In Vitro: Ferrostatin-1 is the most potent inhibitor of erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1 does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS[1]. Cells pretreated with 0.4 μM Ferrostatin-1 displays significantly reduce intracellular reactive oxygen species (ROS) and nitrogen species (RNS) below basal levels. Additionally, increased intracellular ROS levels are also significantly lowered below basal levels by a 0.4 µM Ferrostatin-1 pretreatment. Ferrostatin-1 treatment for 24 h does not change the expression level of i-NOS in SHSY-5Y cell when compare with vehicle (0.02 % DMSO) treated cells[2].
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