ITX3 NLT 98%
Product Number : MC550179
CAS Number : 347323-96-0
Molecular Formula : C22H17N3OS | Molecular Weight : 371.45
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
| MolCore specializes in manufacturing high-purity CAS No.347323-96-0, ITX3 with the molecular formula C22H17N3OS and molecular weight 371.45 delivering critical API intermediates for global pharmaceutical and research industries, certified under ISO quality systems. | |
* The above information is for reference only.
| Chemical Name | ITX3 |
|---|---|
| CAS Number | 347323-96-0 |
| MDL Number | MFCD02629172 |
| Molecular Formula | C22H17N3OS |
| Molecular Weight | 371.45 |
ITX3 is a specific and nontoxic inhibitor of the TrioN (N-terminal GEF domain of the multidomain Trio protein) with IC50 of 76 uM; inhibits TrioN-stimulated RhoG exchange in vitro. IC50 value: 76 uM [1] Target: TrioN inhibitor In transfected mammalian cells, ITX3 blocked TrioN-mediated dorsal membrane ruffling and Rac1 activation while having no effect on GEF337-, Tiam1-, or Vav2-mediated RhoA or Rac1 activation. ITX3 specifically inhibited endogenous TrioN activity, as evidenced by its ability to inhibit neurite outgrowth in nerve growth factor (NGF)–stimulated PC12 cells or C2C12 differentiation into myotubes [1]. ITX3 repressed the Rac1 activity and dose dependently up-regulated the E-cadherin protein level in the Tara-KD cells [2].
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