SKU : MC551208
CAS Number : 36322-90-4
Molecular Formula : C15H13N3O4S | Molecular Weight : 331.35
Synonyms : CP-16171
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Piroxicam |
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CAS Number | 36322-90-4 |
MDL Number | MFCD00057317 |
Molecular Formula | C15H13N3O4S |
Molecular Weight | 331.35 |
Synonyms | CP-16171 |
Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively. IC50 & Target: IC50: 47 μM (COX-1, in human monocytes), 25 μM (COX-2, human monocytes)[1] In Vitro: Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively[1]. Piroxicam (CP-16171) (167, 333, 500 μM) decreases cell population of T24 and the 5637 cells. Piroxicam (CP-16171) (500 μM) also reduces the cell viability of T24 and 5637 cell, and is significantly effective when combined with 0.05 μM carboplatin. The combination also inhibits Ki-67 expression in booth cells[3]. In Vivo: Piroxicam (CP-16171) (0.3 mg/kg qd 24-h p.o.) reduces tumor volume in 12 of 18 dogs, and such and effect is via induction of apoptosis and reduction in urine basic fibroblast growth factor concentration[2].
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