SKU : MC552058
CAS Number : 3785-24-8
Molecular Formula : C13H12O3 | Molecular Weight : 216.23
Synonyms : Musizin
Quote RequestPurity | NLT 98% |
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Storage | at 20ºC 2 years |
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Chemical Name | Nepodin |
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CAS Number | 3785-24-8 |
MDL Number | MFCD00238579 |
Molecular Formula | C13H12O3 |
Molecular Weight | 216.23 |
Synonyms | Musizin |
Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities. In Vitro: Nepodin (Musizin) exhibits significant IC50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively[1].
In Vivo: Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner[2].
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