JTE-013 NLT 98%
Product Number : MC552327
CAS Number : 383150-41-2
Molecular Formula : C17H19Cl2N7O | Molecular Weight : 408.29
Quote Request| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
| MolCore specializes in manufacturing high-purity CAS No.383150-41-2, JTE-013 with the molecular formula C17H19Cl2N7O and molecular weight 408.29 delivering critical API intermediates for global pharmaceutical and research industries, certified under ISO quality systems. | |
* The above information is for reference only.
| Chemical Name | JTE-013 |
|---|---|
| CAS Number | 383150-41-2 |
| MDL Number | MFCD09878275 |
| Molecular Formula | C17H19Cl2N7O |
| Molecular Weight | 408.29 |
JTE-013 is a potent and specific S1P2 (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P2 with IC50s of 17 nM and 22 nM, respectively[1]. IC50 & Target: IC50: 17 nM (S1P2 for human) and 22 nM (S1P2 for rat)[1] In Vitro: JTE-013 (50-200 μM; 1-3 days) reduced cell viability[1].
JTE-013 (10-1000 nM; 30 mins) reverses S1P-induced Akt inhibition and inhibits S1P-induced ERK activation[1].
JTE-013 displays 4.2% inhibition of S1P3 and does not antagonize S1P1 at concentrations up to 10 μM[1]. In Vivo: JTE-013 (gavage; 30 mg/kg daily for 14 consecutive days) reduces tumor size and tumor weight[1].
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