Thiomethyl resin (200-400 mesh) 98% Min.

This "polymeric thiol" binds to electrophilic substrates, e.g. via Michael addition and may thus act as a scavenger for electrophilic reagents and as a support for SPOS. Kobayashi et al. employed this support in the preparation of immobilized silyl enol ethers, which have been utilized in solid phase aldol reactions, Mannich reactions and in the synthesis of monosaccharide derivatives. Barco and coworkers prepared polymer-bound sulfonylphosphoranes as intermediates in the synthesis of substituted piperidinones.Cleavage of thioesters derived from this support has been effected with LiBH₄, diisobutylaluminium hydride and NaOH to afford alcohols, aldehydes and carboxylic acids, respectively.